It's kinda funny since I never draw it, but my biggest Karkat ship is Karkat <> Kanaya. Legit. I was pushing for them to be moirails like no other. But my Homestuck OTP will always be Suffs x Disciple. They hit me RIGHT in the FEELS. XD
Oh MAN I have a whole whirlwind of feelings about John/Vris. I never draw them because I can't draw Egbert worth a damn, but they're so sweet and heartbreaking and he changed her so much for the better and then HE DIDN'T REMEMBER HER asdfghjkl kill me with feels.